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A complete of three % of Energetic compound is excreted in urine as unchanged Lively substance. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, which are additional metabolised by conjugation. Thus, active material metabolism mediated by cytochrome P450 me